Jodantipyrin |

Iodantipyrin (1-fenil-2,3-dimetil-4-iodpirzalon) -the medicine is in form of drug (of 0,1 gr.) and authorized by the Ministry of Public Healthcare of the Rus-sian Federation in order to use it for the treatment (registration licenses 96/316/2 and 96/316/5).
Antivirus activity of Iodantipyrin is the best way for the treatment of non-polemielitic viruses Koksaki (А13, А18, А21, В1, В4, В6) and ЕСНО 11, viruses of vesicular stomatite, mite infection, grippe and poligrippe. Ingibular dosage of medicine (ID50) in relation to the range of test- viruses in the culture of the large cells of hens’ embryos is 5 – 10 mkg/kg, chemical and therapeutic index - 100-200.
Iodantipyrin has interferon stimulating activity in the body of mouse and culture of splenocites, inducing the creation of Alfa and beta interferon that in some way explains antiviral activity of the connection [3].
Studyings of immune characteristics of Iodantipyrin have shown it immu-nomodulatiting effect towards the erythrocyte and virus antigens [1]. The results of implementation of the medicine to rats have shown that it stimulated B-chain of the immunity (increasing the number of anti body creating cells in the spleen and lymphocytes of the peripheral blood) and moniciterian sprout of the bone brain blood-making, helps the collection of small leukocytes in the lymphoid parts and the expression of Fc – receptors on the mononuclear of peritoneal ecsudate.
The combination of antivirus, interferoginial and immunostimulating activ-ity of Iodantipyrin was the base for its tests as the medicine against grippe infec-tions. The double blind clinical and epidemiological test have investigated that Iodantipyrin is of high efficiency for the patients having contact with sick people subbering from the grippe during epidemics of A and B grippe. The medicine was taken according to the two schemes: I – at the dosage of 200 mg. two times a week; II – 100 mg. during 7 days. After the three-day pause the course was re-peated; Iodantipyrin was taken according to the two schemes during the whole epidemic season. Workers of the two Tomsk enterprises have participated in the experiment. 97 on the first enterprise, 36 of them have not taken Iodantipyrin (control group) and 61 have taken it on the first scheme; 344 - on the second one, 172 of them have taken Iodantipyrin on the second scheme and 172 have not taken it at all (control).
According to the results of the control over those who were in the main and control groups the following indexes of the efficiency (K) and protection (E) on formulas have been got:
К = В/А; Е = (В х А) / В х 100, где
А – part of those who have been taken ill and have used Iodantipyrin;
В - part of those who have been taken ill and have not use Iodantipyrin.
Also the gravity of the clinical state of people, frequency and side effects because of taking Iodantipyrin, state of peripheral blood and liver (activity of AlAT, AsAT and alkali phosphfatase [8, 10]), sub popular structure of lympho-cytes were studied. They were studied in the citotoxic test [5] with the help of mo-nocular antibodies tawards the differential antigens of a man lymphocyte produced by the «Sorbent» firm (Moscow). Fagocitarian activity of neutrophils was appre-ciated by theirs capacity of absorbing inert particles of melamine pholmaldegite latecs [5] in the blood whey with the help of radial immunodiffusion method [5], the level of the main classes of imunoglobulins (IgM, IgG, IgA) and circulated immune complexes (CIC) [9] have been researched. As well as the track record of inphernonformations by the definition of alpha-interferon quantity in the whey of the blood by the immunonferment hard phased method with the usage of ProCon LF2 plus sets, TOS “Proteinoviy contour” (Saint-Petersburg city) production. The activity of interferon in the monolayer of vaccinating cells was also measured [4].
Laboratory investigations were carried in two groups of 20 men, taking Io-dantipyrin on I and II schemes, before starting taking it (1 point), in two (2 point), four (3 point) weeks after the beginning of preventive implementation of Iodanti-pyrin course.
Iodantipyrin preventive effect was appreciated on the criteria of being taken ill by the grippe and other respiratory viral infection in the main control groups. Disease among the people who have taken Iodantipyrin on the I scheme was 9,8%, and in the corresponding control group - 33,3%, i.e. the index of efficiency in this case was equal to 3,4, and the index of protection was 70,6%. Disease among the people who have taken Iodantipyrin on the II scheme was 4,68%, and in the con-trol group – 42,4%, i.e. using Iodantipyrin on the II scheme one succeeded to re-duce disease in 9,2 times (index of efficiency in this case – 9,2; and index of pro-tection – 89,1%).
People who have taken Iodantipyrin had the following clinical symptoms: weak Qatar phenomenon, fever for a short period of time, lack of intoxication; they also did not ask for medical help. Those who have not taken Iodantipyrin had more serious and longer chronic symptoms: high temperature over 38 (for 3 days), clear indicators of intoxication and Qatar.
5 men out of 61 (8,2%) had side effects because of taking Iodantipyrin on the I scheme; two of them (3,3%) had a slight pain in the sphere of epee gastritis: one (1,6%) in the right side, under the rib, one (1,6%) - has a tickling sensation in his throat, one (1,6%) – was not well.
5 men out of 172 (2,9%) had side effects because of taking Iodantipyrin on the II scheme; three of them (1,7%) had short time headache, one (0,6%) – sick-ness, one (0,6%) – diarrhea. Side effects were weak and short. Thus one can see that usage Iodantipyrin on the II scheme have caused 2,8 times less side effects then on the I one.
Our experience have shown that Iodantipyrin helps normalizing the state of peripheral blood of the volunteers who had a bit rising SOE and a shift of the leu-kocyte formula in this or that side.
The control over the dynamic of biochemical indicators of the liver func-tional state helped to conclude that Iodantipyrin in the dosage witch have been chosen does not have toxic effect on the hepatitis system of adults.
Analyzing the data of the immune monitoring among the people taking Io-dantipyrin on the first scheme, one may conclude that the dynamic of studied indi-cators is appropriate to the mechanisms of the immune reaction on its early stages. In 14 days after the beginning of taking the medicine the cell section of the immu-nity has become active: the absolute quantity of leukocytes, lymphocytes and prac-tically all subpopulations of the last ones increases considerably in statistic. The contents of lymphocytes CD8+ (mature T – cells) have increased considerable that is an evident of classical way of T-lymphocytes activity inclusion. The quantity of CD8+ cells (T-killers/suppressors) actively regulating inter cell connections, abso-lute as well as comparative quantity of B-lymphocytes and natural killers (CD72+ and CD16+), having the function of cell-effectors, have also increased. By the end of observation all mediocre indicators of the cell immunity in this group were back to the original level.
While studying the factors of gumoral immunity of this group patients the evident increase of IgM concentration in the blood whey, reaching the maximum on the 28th day of observation, gradual decrease of the IgG content and consider-able IgA stability have been stated. The quantity of CIK in the peripheral blood increases slowly, and the percentage of fagociterian cell without considerable changing of their functional activity (fagociterian number) rises slightly during the process of taking Iodantipyrin.
In the group of patients taking Iodantipyrin on the II scheme one does not observe such an active restructure of the immune system.
Interferon activity in the blood whey of patients have increased considerably from the first day of taking drug and lasted until the end of observation. Only the patients taking Iodantipyrin have a high concentration of interferon in the blood sperum (more then 500 pkg/ml): in 25% of the cases on the I scheme, in 44% of cases on the II.
Thus analysis of the possible mechanisms of prevention activity of Yodanti-pyrin shows the capacity of this medicine to be the inductor of interferon.

CONCLUSIONS
1. Yodantipyrin is an effective agent in prevention of the grippe and other acute respirotary viral infections.
2. The most effective, harmless and intensive by interferon formation seems to be the scheme of taking Yodantipyrin at the dosage of 100 mg/ for 7 days with repetition of the given course at 3 days interval during the period of epidemic season all in prevention of the grippe and other acute respiratory viral infections.
3. Clinical manifestations of infection process in persons who had fallen ill with the grippe or ARV while taking Iodantipyrin were characterized by the lack of evident intoxication, a mild course of a disease and quick recovery; side effects of Iodantipyrine were in-significant and of short duration.
The other schemes of protection against the grippe with the help of Iodantiperin have been worked out at present (see an application).

IODANTIPYRIN – NEW ANTIVIRUS MEDICINE FOR EXTREME PREVENTION MAINTENANCE AND TREATMENT OF TICK ENCEPHALITIS

Worked out:
By the Siberian state medical university, Tomsk
(Head of the infectional diseases chair with epidemiology SGMU, doctor of medical sciences, professor A.V. Lepechin);
Regoinal
(Head of the epid department E.N. Topovskaya,
head of the parasitic department O.A. Sokerina)
Healthcare department of the Tomsk region
(head infectionologist Z.I. Zorina)

Reviewer
Head of microbiology chair department SGMU, doctor of medical sciences, professor E. P.Krasnozhenov

Approved
By the scientific council SGMU 06.04.99

Introduction

Tick encephalitis (TE) is a one of the widely spreading neuroinfection in Russia. 60 years have already passed since putting this disease in the independent pathology. But this problem is still actual. That is why intensive researches are caring out in this sphere.
In spite of great success in the prevention of TE which were reached with the help of the implementation of active immunization into the medical practice the disease affection was reduced 8-9 times). The final resolution of this problem demands its logic continuation, as there are great numbers of people, which cannot take the active immunization because of their health. Physicians also meet a lot of questions, connecting with the specific of TE prevention in their every day practice. If the patient stays healthy during all the vaccination and revaccination cycle, his physician has no problems. But the majority of the inoculated patients may have various diseases in the proper terms of vaccination and revaccination which demand either total refuse of the vaccination process or violate its regulations. In the last few years one could mention an increase in the spread of such diseases like tuberculosis, various allergies, chronic disease of liver, kidneys, cardio-vascular systems, various endocrine pathologies, as well as malignant tumours, blood diseases, progressive and degranulative violations of nervous system etc. which are contra indications to the vaccination against TE. There are thousands of such patients in the TE natural hearths.
That is why one should take into the consideration more wide use of ethiotropic effect drugs, violating TE virus life cycle and blocking its reproduction at the stage of infection. To the number of such drugs one can add Immunoglobulin against TE and Iodantipyrin. The first drug is used for the emergency preventive maintenance against TE during rather long period of time. Iodantipyrin is used with such a purpose for the fist time.
The instructions describe these drugs, characterizing theirs pluses and minuses. Here you can also find optimal schemes of its usage with the purpose of TE prevention.

2.Imunoglobulin against tick encephalitis, human, liquid for intermascular injection.
The medicine represents the concentrated solution of the immunoglobulin-cleared fraction (10-16 %), allocated by an alcohol method from plasma or serum of human donor blood containing specific antibodies to a virus TE (titer in RPGA not less then 1:80). The mechanism of action of a medicine is connected with the virus neutralization by antibodies.
The medicine is used for emergency preventive maintenance in the TE hearths in the following cases: to the patients who were not inoculated and a tick has sticked to them; if such sticking was massive then the medicine is injected to the inoculated people as well; in case of repeated infection in 1-1,5 month after the first one; in case of the probability of the infection in a laboratory.
In all these cases the medicine should be injected as soon as possible from the moment of supposed infection.
For the purpose of emergency preventive maintenance the medicine should be introduced into the muscles one time at the age of up to 12 – 0,1ml, from 12 till 16 years - 2 ml, more senior than 16 years - 3,0 ml.
Before the injection an ampoule with Immunoglobulin is maintained at a room temperature within 2 hours. In order to prevent formation of foam the medicine is collected in a syringe by a needle with a wide gleam.
In rare cases Immunoglobulin injection may be followed by such reaction as increase of temperature of a body up to 37,5оС, the development of anitifilactic shock is rather rare.

3. Iodantipyrin (Iodantipirinum)
Iodantipyrin – (1 fenil 2-3 dymethil 4 iodpirzalon) –a white crystalline powder with a weak smell does not practically dissolve in water and does not have mutator gene, embryotoxic, immunotoxic and allergic effect. It is an alpha and beta interferons inductor, has antivirus, antiiflamation, immunomodulating effect. In 1996 the medicine was authorized by the Ministry of public health services of Russian Federation for application as a means for emergency preventive maintenance and treatment of TE.
When the tick has already sticked Iodantipyrin is taken inside according to the following scheme: at the dosage of 300 mg. (3 tablets) 3 times per day within first two days; at the dosage of 200 mg. (2 tablets) 3 times per day within the next two days; at the dosage of 100 mg. (1 tablet) 3 times per day during the next 5 days.
During all period of stay in the TE endemic center Iodantiperin was prescribed to adults on 200 mg. (2 tablets) once per day.
Allergic reactions may have place in case of Iodantipyrin taking such as increased sensitivity to the iodine medicines.
Sometimes Iodantiperyn taking can cause allergic reactions connected with an increased sensitivity to the iodine preparations.

4.Comparative efficiency of preventive effect of Immunoglobulin and Iodantipyrin against tick encephalitis
For studying of Immunoglobulin and Iodantipyrin specific efficiency at emergency preventive maintenance of TE in case of infection after the tick sticking 3 groups were formed: first group included the patients, which have taken Iodantipyrin against TE in preventive aims (460 men); second group – Immunoglobulin against TE (11195 men); third one – those who have not had the emergency preventive maintenance (467). Only patients with TE virus, which was found either in a tick or in blood, were included in these groups
Is was established, that out of 11195 men, with which injected by the specific Immunoglobulin after the tick sticking 201 men (1,79 %) had TE; the index of disease was a bit higher in the group, where the emergency preventive maintenance were not done at all: 10 from 467 men was ill in such case, that has made 2,1 %. Iodanipyrin was more effective in comparison with the specific Immunoglobulin: out of 460 men taking the given medicine only three were ill (0,65%).
The studying of Iodantipyrin protective mechanism has shown, that one of the major factors of its preventive action is an expressed stimulation of alpha and beta interferon generating. In 4 hours after taking of the medicine the level of these antivirus proteins increases in tens times, in 12 and 24 hours in hundreds and thousands times. Thus the considerable stimulation of cell and gumoral immunity has place.
As is known, the TE virus can already penetrate into the men body in several minutes after the tick sticking. The longer the virus forming tick stays in the place of sticking, the larger doze of the virus it injects into the man body. This and other factors (overstrain, overheating, overcooling, reception of alcohol) cause shorter incubation period of the disease lasted one day or several hours. That is why all medical workers should have the strict rule to carry out an emergency preventive maintenance as early as possible and with the help of the medicines listed below. All population living in the natural TE hearths should be informed about this rule.
The detailed studying of the data listed in the table has shown that those who have got the emergency preventive maintenance later than the second day from the moment of the tick sticking became ill by TE in both groups.

5. Some advantages and disadvantages of the TE emergency preventive maintenance, carried out with help of specific Immunoglobulin and Iodantipyrin

A. Immunoglobulin against TE;human liquid for inter muscular injection
Advantages: high specificity - quickly neutralization of the virus, circulating in blood; is capable to protect a cell from the virus, connecting with it surface membrane receptors; in a number of cases neutralizes the virus inside a cell, penetrating in it with the help of linkage with cytopllasmatic receptors.

Disadvantages (are mainly connected with carrying out of the emergency preventive maintenance methods): lack of the highly circulated Immunoglobulin in practical public health services; the impossibility of the emergency preventive maintenance realization at the very moment of the sticking tick discovery as the injured can be far from the seropreventive station at this time; the necessity of the additional expenses for the purchase of syringes, cotton wool, spirit and other auxiliary materials.

B. Iodantipyrin
Advantages: a chemical medicine with a wide spectrum of action, has antivirus, interferogene, immunomodulating and antiinflamatory effects; the medicine is much cheaper than the specific Immunoglobulin; it can be bought in a chemist's network and have it with you constantly, as its storage does not demand any special conditions.
Disadvantages: are mainly connected with the raised sensitivity to this medicine as well as to all iodine medicines.

THE CONCLUSION
Generalization and systematization of the experience of TE emergency preventive maintenance by the medicines which effect is connected with specific and common violations of the virus life strategy have shown that both compared medicines (specific Immunoglobulin and Iodantipyrin give the positive preventive effect.
Is pleasant to note, that one more medicine (Iodantipyrin ) has appeared in Russia which can be successfully used for the emergency preventive maintenance of tick encephalitis and, if it is necessary, be used according to the schemes listed above.

M.A.Vnushinskaja
EFFICIENCY OF IODANTIPYRININ TREATMENT
CHRONIC HEPATITES B
The Siberian state medical university, Tomsk,
Limited liability company “ Nauka. Technica. Medicina ”, Tomsk

INTPODUCTION
Iodantipyrin – (1 fenil 2-3 dymethil 4 iodpirzalon) –a white crystalline powder with a weak smell does not practically dissolve in water and does not have mutator gene, embryotoxic, immunotoxic and allergic effect. This medicine belongs to the group of nesteroid anti-inflammatory drugs, pyrasole derivatives and is an inductor of alpha and beta interferons. The medicine is authorized to use in medical practice (The ministry of public healthcare order from 13.08.96 №316) and manufactured serially (registration certificate 96/16/5).

PHARMACOLOGICAL CARECTERISTICS
Iodantipyrin anti-inflammatory effect is complex. The main components of such effect are appeared in the following mechanisms. Iodantipyrin reduces the degranulation of the granule cell, suppresses ferments, synthesizing postanglandines; impedes arachidon acid synthesis, has membrane stabilizing effect on the cellular membranes, reduces the intensity of the biological oxidation and phosphorilin processes connecting with them.
Iodantyperyn effect is based on its capacity to suppress biosynthesis and prostaglandin activity that in their turn has an igibular effect on interferon production. The experiment shows that the medicine is able to suppress the reproduction of DNA, RNA viruses in cells cultures, stabilize biological membranes and energy exchange that can impede virus implementation to a cell.
Iodantipyrin induces interferon (late beta crystal interferon induction with the maximum point of generation by 48 hours as well as alpha interferon one). It also has immunomodulating effect (the complex of Interferon pharmacological characteristics with antivirus and anti-inflammatory activity, capacity to induce the synthesis of antibodies, neutralizing viruses and to stimulate cellular and humoral immunity).
Iodantipyrin possesses the complex of the following characteristics such as anti-inflammatory, antiproliferative, virus neutralizing and immune corrigulative. It is the complex of all this Iodantiperin characteristics that helps to use it broadly in clinical spheres.

PURPOSE OF RESEARCH is to study Iodantipyrin clinical efficacy in a case of taking it by the patients with the chronic, virus hepatitis.

CRITERIA OF INVOLVEMENT INTO THE RESEARCH
The research was carried out openly at dispensary and hospital conditions on the basis of the regional consultative polyclinic and the day stationary of the Regional Clinic Hospital. Patients at the age of 18-50, which can use antiviral drugs as entiopatogenal medicine for the treatment of the chronic virus hepatitis were involved in the research.

CRITERIA OF TEST EXCLUSION
The medicine was stopped to use in case of complications and side effects and at the demand of a patient if it seems to be ineffective.
Contra indication was individual disability to take medicines with iodine.

METHODS OF TAKING AND DOSAGE
Iodantipyrin is prescribed at the dosage of 100 mg. in a pill, after food, 2 times a day, 4 times a weak. The duration of the course was 6 months.
By the end of the fist month of Iodantipyrin taking one can observe the reduction of subjective symptoms of the liver function breaking and degree of theirs indication. Particularly noticeable was the reduction of dyspepsia phenomena, astenia, atralgia, subfebrilithet, feeling of heaviness in the right subribal part. Maximum clinical effect was reached by the third month of the treatment and maintained during the next three months of control. There were no any real differences in the control group in comparison with the dynamic of subjective characteristic of disease (p,05).

DYNAMICS OF ULTROSONIC INSPECTION AND HEPATOBILISCITINGRAPHIA
The indicators of the liver affection characterized by the growth of its size, echogene increase, its structure changes.
During the process of Iodantiperin treatment one observed the improvement of the liver condition, its echo-structure. It was found out that lever of 20 was increased (16 observations), diffuse changes of its parenchyma (18 observations), unequal distribution of RFP with the sections of the reducing of its generation in different parts (12 observations) at the initial hepatobiliscitingraphia. 16 of these patients were subjected to the repeat research in 6 months. The liver of 14 patients (87,5%) was reduced in size; diffuse changes of 9 (56,25%) patients (56,25%) became less marked in the parenchyma of liver.

DYNAMICS OF BLOOD BIOCHEMICAL INDICATORS AT THE COURSE TREATMENT BY IODANTIPYRIN
At the initial research the change of the main blood biochemical indicators appeared by the syndrome of cytolyses with 2-3 times increase of aminotransferases level. The tendency towards the increase of alkali phosphatase, 76,6+-3,0
characterizing holestatic syndrome was marked.
An improvement of the indicators which shown the liver functional state was marked by the end of the month. Most essential recovery of the AST, ALT, alkali phosphatase level was marked by the end of the third month of the treatment. After the process of taking this drug the activity of aminotranspherases was normal in both groups.
The dynamics of biochemical indicators in the test group with the data of the 10 patients in comparative group, taking amiksin was compared. Any real differences were not mentioned. (p more then 0,05).
The dynamics of the immunogram indicators of the basic group was studied. During the process of the course taking of Iodantipyrin one marked the normalization of the T cells chain, unspecific resistention factors.

DYNAMICS OF HEPATITIS VIRUS MARKERS
Iodantipyrin taking during 6 months suppressed the replicative phase of the virus infection (PCR -) at 26,5 patients (53 %).
During the process of amiksin taking only 4,3 patients (43 %) had no replicative phase at the same terms.

COMPLICATIONS AND SIDE EFFECTS
No deterioration was marked in the following organs: thyroid gland, kidneys, gullet and stomach as well as the functional state of the other organs. There was also marked good overbearing of the medicine and the lack of the side effects in one time and course taking of Iodantipyrin.

CONCLUSIIONS
1. Iodantipyrin at the dosage of 200 mg. 4 times a week during the 6 month course taking positively effects clinical symptomatic, leveling the cytolysis syndrome at the patients with the chronicle hepatitis B, C in to the replicative phase.
2. The medicine has antivirus effect, suppressing the replicative phase at the majority of the patients with hepatitis B and C.
3. The medicine has immunomodulating effect with the primary effect on the cell immunity indicators and unspecific resistention factors.
4. One can mentioned the good overbearing of the medicine by the patients and the lack of the side effects.

CLINICAL STUDYING OF IODANTIPERIN AS THE MEDICINE FOR THE TREATMENT OF HEMORRHAGIC FEVER WITH KIDNEY SYNDROME

Pharmacology Clinical tests of Iodantiperin were carried out in the infection hospital № 4 of the city of Ufa according to the permission of the State Committee of Public Healthcare of the Russian Federation.
The aim of this research work was studying Iodantiperin as the medicine for the treatment of hemorrhagic fever with kidney syndrome (HFKS) in the clinical conditions.
The following task were resolved during the studying:
1. To work out and implement in the medical practice optimal schemes of treating patients having HFKS with the help of Iodantiperin.
2. To find out side effects and contral-indications.

RESEARCH METHODS
While choosing the patients in order to treat them with the help of Iodantiperin we took into the consideration that the treatment of the patients with the light form of HFKS is limited to the diet and staying in bed and treatment with the help of drugs is minimized.
In order to appreciate the effectiveness of therapy all patients were divided in 2 groups. 67 patients in the first one (49 of them with the medium heavy and 18 with the heavy forms of HFKS) have got generally accepted pathogenic therapy (desintoxical medicines, spasmodic, antigestamin drugs, analgetics and vitamins) and became a control group. The second one composed of 74 patients (49 of them with the medium heavy and 18 with the heavy forms of HFKS) in addition to the common therapy has taken Iodantiperin.
Such therapy had the following contral-indications: individual negative reaction, hyperfunction of the thyroid gland that was presumed by the instruction, as this medicine has iodine.
The following methods of treatment were applied: the medicine was prescribed perorally at the early stages of the disease, not later then after the fifth day of disease after food, at the dosage of 0,2 gr. (2 pills) three times a day during the first four days, then at the dosage of 0,1 gr. (1 pill) three times a day for the next five days.

RESULTS OF THE RESEARCH

The following clinical indicators were used in order to point out the efficacy of therapy:
1. Clinical – fever, pain syndrome and oliguria duration.
2. Biochemical – extreme levels of urea and creatinin.
3. Dynamic of some immunity indicators – subpopulation of CD 3, CD 4, CD 8 lymphocytes, fagociterian index, B-lymphocite.
4. Dynamic of the interferon status indicators – serum IFS, alpha-IFS.
While appreciating the positive effect of the immune modulating therapy, clinical efficacy criterion was used first of all.
The duration of such symptoms as fever, oliguria, pain in the loin and abdomen was really less serious at the patients with the average serious form of HFKS taking Iodantipyrin than at the control group ones.
The essential reducing of the urea and creatin extreme indicators was also found out in the test group. The duration of the fever and pains in the loin at the patients having the serious form of HFKS and taking Iodantiperyn was really different. The difference in the duration of oliguria, pains in the abdomen and headache at the patients of both groups was doubtful, the extreme indicators of the creatinin were really lower in the test group and urea ones were not really different.
According to the worked out scheme, Iodantiperin was easily endured. Side effects and allergic reactions were not registered.
But it is necessary to mention that people having vomiting must abstain from using it.
The results of the studying CD 3, CD 4, CD 8 lymphocytes, fagociterian index, B- lymphocytes have shown that the dynamic of the cell immunity indicators depends on the degree of HFKS patient’s state.
There was no certain difference between the immunologic indexes in oligurial period in these groups. One observed the increase of the comparative quantity of CD 3, CD 4 lymphocytes during the medium heavy and heavy forms of HFKS in the polyuric period. As far as CD 8 lymphocytes is concerned the obtained data are rather contradictional: there was no any certain definition at medium heavy form in both groups, while the index in the test group at heavy form was realistically lower then in the control one. Neutrophiles fagocytose in the test group during the polyuric period was characterized by the high indication of fagocyterian indexes. Realistically lower indexes of B-lymphocite have been found out. The comparative quantity of CD 3, CD 4, CD 8 lymphocite subpopulation are realistically higher in the test group, approaching to the healthy men ones during the reconvalensetional period at the medium heavy form. Fagociterian index indicators and B-lymphocytes had no certain difference in the groups. At the heavy form one may observe the common tendency of the cell immunity stabilization, but statistically trustworthy difference have not been revealed in both groups.
Thus analyzing above mentioned characteristics of the cell immunity in the two groups of patients one may conclude the existence of the immunomodulating effect of Iodantipyrin at the patients with the medium heavy and heavy forms of HFKS).
Fast growth of the interferon saturation (IFS) system activity has been truly found out during the early stages of Iodantipyrin prescription.
As table 5 shows no essential difference were find out in the IFS serumal titer growth during the oliguria and poligurial periods in the test groups. By the time of discharge the level of the serumal IFS in the test group was really lower then in the control one. The increase of the leukocyte capacity to the alpha-IFS has appeared later to the reconvalensetion in the test group. The level of the serumal IFS was high during all periods of the disease at the heavy form of HFKS in both groups and was really the same. The level of alpha-IFS was reduced at the patients of the medium heavy form of disease in comparison to the same indicator. During the period of reconvalensetion the level of alpha-IFS had a tendency to the growth, which was more marked in the test group. But there were no real definition between the indicators.
The high IFS serumal titer at the height of the disease were probably connected with high interferon activity of blood cells as well as the other systems involved in the pathological process and interferogenal activity of the HFKS virus itself.
An increase of the leucocite capacity to produce alpfa-IFS during the oliguria period was observed. It was probably connected with the depressed effect of the HFKS virus on the alpha-IFS production. The increase of the leukocyte capacity to generate alpha-IFS during the recreation period agreed with known data concerning the normalization of the citric and gumoral immunity indicators at the same periods.
Thus, early prescription of Iodantipyrin was conductive to the fastest growing increase of the interferon synthesize capacity of leucocites at the medium heavy and heavy forms of HFKS, but such capacity was more pronounced at the patients with the average serious form.
Having anti-inflammatory effect Iodantipyrin, apparently, influences the level of virus and more fast decrease of temperature is an indicator of this. One of Iodantipyrin effect mechanism is a delay of the virus penetration to cell, the induction of interferon and antibodies synthesis. The effect of this is an interruption of the pathologic process.
The marked positive effect of Iodantiperin application helps to explain the practicability of interferon inductors application in the structure of the complex therapy with the average serious and serious forms of HFKS.

CONCLUSIONS:
1. Iodantipyrin indicates considerable therapeutic efficacy if it was prescribed at early stages of disease (up to the fifth day of disease). It also contributes faster dynamic of the main clinical symptoms and indicators, characterizing functional capacity of kidneys.
2. Iodantipyrin, proposed for immunocorrection and antiviral effect, it also stimulates the factors of the cell immunity and interferongenesis system.
3. The effects marked below develop if Iodantiperin is prescribed on the following scheme: at the dosage of 0,2 gr. (2 pills) three times a day for the first three days then at the dosage of 0,1 gr. (1 pill) three times a day for the next five days. The whole course is equal to nine days.
4. Iodantipyrin may be recommended as the medicine in the complex therapy to the average serious and serious forms of HFKS.
5. Taking into the consideration the clinical efficacy, lack of side effects, comfortable individual applying, moderateness, proved effectiveness in prevention of the grippe and other acute respiratory viral infections, one recommend to prescribe it in the dispensary conditions as well, from the fist days of the virus infection effect in order to ease the following development of the disease.